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KMID : 0380019940090050506
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Korean Journal of Biotechnology and Bioengineering
1994 Volume.9 No. 5 p.506 ~ p.510
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Antimicrobial Activity of Extracts and Coumaric Acid Isolated from Artemisia princeps var. orientalis
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Abstract
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Antimicrobial activity of methanol extract and fraction from mugwort leaves( Artemisia princeps var. orientalis) was investigated for the screening of natural antimicrobial components. By using agar diffusion method, ethyl acetate(EtOAc) layer fractionated from methanol extract of mugwort leaves showed the highest inhibitory effects against tested microorganisms. The ortho-coumaric acid(200-600ppm) isolated from EtOAc layer showed strong antibacterial activities for Bacillus subtilis and Salmonella typhimurium. As derivatives of o-coumaric acid, antibacterial activity of para-coumaric acid was 1.2-1.7 fold higher than that of o-coumaric acid. Three types of coumaric acids strong inhibited
the growth of B. subtilis in the culture medium Growth of S. tvphimurium, P. aeruginosa and S. aureus
were effectively inhibited by o-, m- and p-coumaric acids, respectively. Minimum inhibitory dose of pcoumaric acid for B. subtilis was 100- 200w/paper disk.
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